Ranolazine and Clarithromycin

Desk tier: Avoid together

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“Ranolazine is contraindicated in patients: Taking strong inhibitors of CYP3A … Strong CYP3A inhibitors (e.g., ketoconazole, clarithromycin, nelfinavir)”

Ranolazine extended-release, section 4 CONTRAINDICATIONS. DailyMed label

Open this pair in the desk

All pairs for Ranolazine · Clarithromycin

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.