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Ranolazine and Primidone

Desk tier: Avoid together

Mechanism: moderate CYP3A4 induction of clearance (↓ exposure / loss of efficacy)

“RANEXA is contraindicated in patients: … Taking inducers of CYP3A”
Ranexa (ranolazine), section 4 CONTRAINDICATIONS. DailyMed label

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All pairs for Ranolazine · Primidone

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.