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Rifampin and Atazanavir

Desk tier: Avoid together

Mechanism: strong CYP3A4 induction of clearance (↓ exposure / loss of efficacy)

“Rifampin is contraindicated in patients who are also receiving atazanavir, darunavir, fosamprenavir, saquinavir, tipranavir”
Rifadin (rifampin), section CONTRAINDICATIONS. DailyMed label

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All pairs for Rifampin · Atazanavir

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.