All pairs

Rilpivirine and Phenobarbital

Desk tier: Avoid together

Mechanism: moderate CYP3A4 induction of clearance (↓ exposure / loss of efficacy)

“EDURANT and EDURANT PED are contraindicated for coadministration with the drugs in Table 2”
Edurant (rilpivirine), section 4 CONTRAINDICATIONS (Table 2). DailyMed label

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All pairs for Rilpivirine · Phenobarbital

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.