Riociguat and Sildenafil

Desk tier: Avoid together

Mechanism: sGC stimulator × PDE5 inhibitor (additive hypotension)

“Concomitant administration of Adempas with specific PDE-5 inhibitors (such as sildenafil, tadalafil, or vardenafil) or nonspecific PDE-5 inhibitors (such as dipyridamole or theophylline) is contraindicated”

Adempas (riociguat), section 4.3 Phosphodiesterase Inhibitors. DailyMed label

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All pairs for Riociguat · Sildenafil

Educational reference only. Not FDA-cleared. The Prescribing Information governs.