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Rivaroxaban and Ketoconazole

Desk tier: Serious concern

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“Avoid concomitant administration of XARELTO with known combined P-gp and strong CYP3A inhibitors (e.g., ketoconazole and ritonavir)”
Xarelto (rivaroxaban), section 7.2 Drugs that Inhibit Cytochrome P450 3A Enzymes. DailyMed label

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All pairs for Rivaroxaban · Ketoconazole

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.