Safinamide and Cyclobenzaprine
Desk tier: Avoid together
Mechanism: MAOI × serotonergic (serotonin syndrome / hypertensive crisis)
“XADAGO is contraindicated in patients with: … cyclobenzaprine”
All pairs for Safinamide · Cyclobenzaprine
Educational reference only. Not FDA-cleared. The Prescribing Information governs.