Safinamide and Methadone

Desk tier: Avoid together

Mechanism: MAOI × serotonergic (serotonin syndrome / hypertensive crisis)

“XADAGO is contraindicated in patients with: … Concomitant use of opioid drugs (e.g., meperidine and its derivatives, methadone, propoxyphene, or tramadol)”

Xadago (safinamide), section 4 CONTRAINDICATIONS. DailyMed label

Open this pair in the desk

All pairs for Safinamide · Methadone

Educational reference only. Not FDA-cleared. The Prescribing Information governs.