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Sildenafil (PAH) and Riociguat

Desk tier: Avoid together

Mechanism: sGC stimulator × PDE5 inhibitor (additive hypotension)

“REVATIO is contraindicated in patients with: … Concomitant use of riociguat, a guanylate cyclase stimulator.”
Revatio (sildenafil), section 4 CONTRAINDICATIONS. DailyMed label

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All pairs for Sildenafil (PAH) · Riociguat

Educational reference only. Not FDA-cleared. The Prescribing Information governs.