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Simvastatin and Clarithromycin

Desk tier: Avoid together

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“Concomitant use of strong CYP3A4 inhibitors (select azole anti-fungals, macrolide antibiotics, anti-viral medications, and nefazodone)”
Zocor (simvastatin), section 4 CONTRAINDICATIONS. DailyMed label

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All pairs for Simvastatin · Clarithromycin

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.