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Suvorexant and Ketoconazole

Desk tier: Serious concern

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“Concomitant use of BELSOMRA with strong inhibitors of CYP3A (e.g., ketoconazole, itraconazole, … is not recommended”
Belsomra (suvorexant), section 7.2 Effects of Other Drugs on BELSOMRA. DailyMed label

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All pairs for Suvorexant · Ketoconazole

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.