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Thioridazine and Fluoxetine

Desk tier: Avoid together

Mechanism: strong CYP2D6 inhibition of clearance (↑ exposure)

“drugs that inhibit this isozyme (e.g., fluoxetine and paroxetine) … thioridazine is contraindicated with these drugs”
Thioridazine HCl tablets, section CONTRAINDICATIONS. DailyMed label

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All pairs for Thioridazine · Fluoxetine

Enzyme behind this pair: CYP2D6

Educational reference only. Not FDA-cleared. The Prescribing Information governs.