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Ticagrelor and Ketoconazole

Desk tier: Serious concern

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“Avoid use of strong inhibitors of CYP3A (e.g., ketoconazole, itraconazole, voriconazole, clarithromycin, nefazodone, ritonavir”
Brilinta (ticagrelor), section 7.1 Strong CYP3A Inhibitors. DailyMed label

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All pairs for Ticagrelor · Ketoconazole

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.