All pairs

Tizanidine and Fluvoxamine

Desk tier: Avoid together

Mechanism: strong CYP1A2 inhibition of clearance (↑ exposure)

“Concomitant use of Zanaflex with strong cytochrome P450 1A2 (CYP1A2) inhibitors (e.g., fluvoxamine, ciprofloxacin) is contraindicated.”
Zanaflex (tizanidine), section 7.1 Strong CYP1A2 Inhibitors (see 4 CONTRAINDICATIONS). DailyMed label

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All pairs for Tizanidine · Fluvoxamine

Enzyme behind this pair: CYP1A2

Educational reference only. Not FDA-cleared. The Prescribing Information governs.