Tranylcypromine and Dextromethorphan
Desk tier: Avoid together
Mechanism: MAOI × serotonergic (serotonin syndrome / hypertensive crisis)
“Concomitant use of PARNATE or use in rapid succession with the products in Table 1 is contraindicated … dextromethorphan”
Why this grade
Parnate (tranylcypromine) label, Contraindications
The Parnate (tranylcypromine) label lists this combination under Contraindications. 4.1 Combination with Certain Drugs: "Concomitant use of PARNATE or use in rapid succession with the products in Table 1 is contraindicated … dextromethorphan" Named in the label: "dextromethorphan" Retrieved from DailyMed 2026-10-19.
Parnate (tranylcypromine) label on DailyMedFDA boxed / safety communication
MAOI labels contraindicate serotonergic agents. Serotonin toxicity, hypertensive crisis.
Search DailyMed for TranylcypromineAll pairs for Tranylcypromine · Dextromethorphan
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