Tranylcypromine and Pseudoephedrine

Desk tier: Avoid together

Mechanism: MAOI × stimulant (hypertensive crisis)

“Concomitant use of PARNATE or use in rapid succession with the products in Table 1 is contraindicated … Sympathomimetic products … vasoconstrictors such as … pseudoephedrine”

Parnate (tranylcypromine), section 4.1 Combination with Certain Drugs. DailyMed label

Why this grade

Parnate (tranylcypromine) label, Contraindications

The Parnate (tranylcypromine) label lists this combination under Contraindications. 4.1 Combination with Certain Drugs: "Concomitant use of PARNATE or use in rapid succession with the products in Table 1 is contraindicated … Sympathomimetic products … vasoconstrictors such as … pseudoephedrine" Named in the label: "pseudoephedrine" Retrieved from DailyMed 2026-10-19.

Parnate (tranylcypromine) label on DailyMed

FDA boxed / safety communication

Amphetamine and methylphenidate labels contraindicate use during or within 14 days after an MAOI (hypertensive crisis). Cocaine, MDMA, and other unlabeled stimulants are the desk extending that label; open the PI.

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Educational reference only. Not FDA-cleared. The Prescribing Information governs.

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