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Tranylcypromine and Tapentadol

Desk tier: Avoid together

Mechanism: MAOI × serotonergic (serotonin syndrome / hypertensive crisis)

“Concomitant use of PARNATE or use in rapid succession with the products in Table 1 is contraindicated … tapentadol”
Parnate (tranylcypromine), section 4.1 Combination with Certain Drugs. DailyMed label

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All pairs for Tranylcypromine · Tapentadol

Educational reference only. Not FDA-cleared. The Prescribing Information governs.