All pairs

Voriconazole and Rifampin

Desk tier: Avoid together

Mechanism: strong CYP2C19 induction of clearance (↓ exposure / loss of efficacy)

“Concomitant use of VFEND is contraindicated with drugs and herbal products that induce CYP2C19, CYP2C9, and/or CYP3A4 … Rifampin”
Vfend (voriconazole), section 4 CONTRAINDICATIONS. DailyMed label

Open this pair in the desk

All pairs for Voriconazole · Rifampin

Enzyme behind this pair: CYP2C19

Educational reference only. Not FDA-cleared. The Prescribing Information governs.