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Vortioxetine and Methylene blue

Desk tier: Avoid together

Mechanism: MAOI × serotonergic (serotonin syndrome / hypertensive crisis)

“Starting TRINTELLIX in a patient who is being treated with MAOIs such as linezolid or intravenous methylene blue is also contraindicated”
Trintellix (vortioxetine), section 4 CONTRAINDICATIONS. DailyMed label

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All pairs for Vortioxetine · Methylene blue

Educational reference only. Not FDA-cleared. The Prescribing Information governs.