Ziprasidone and Mefloquine

Desk tier: Avoid together

Mechanism: combined QT load (additive QT prolongation / TdP)

“ziprasidone is contraindicated: … Therefore, ziprasidone should not be given with:”

Geodon (ziprasidone), section 4.1 QT Prolongation. DailyMed label

Why this grade

Geodon (ziprasidone) label, Contraindications

The Geodon (ziprasidone) label lists this combination under Contraindications. 4.1 QT Prolongation: "ziprasidone is contraindicated: … Therefore, ziprasidone should not be given with:" Named in the label: "mefloquine" Retrieved from DailyMed 2026-10-03.

Open source

Prescribing Information

CredibleMeds-class QT plus methadone / citalopram / ondansetron labels. Not a QTc.

Open source

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All pairs for Ziprasidone · Mefloquine

Educational reference only. Not FDA-cleared. The Prescribing Information governs.

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