Pregabalin interactions on FDA labels
These are pairs with Pregabalin where an FDA label names an interaction, grouped by the desk's grade. A drug that isn't listed here hasn't been cleared as safe with Pregabalin; it just isn't on this list. Open any pair in the desk to see it alongside other drugs.
Serious concern
- Pregabalin and Buprenorphine
Why this grade
Suboxone (buprenorphine/naloxone) film label, 5.3 Managing Risks from Concomitant Use of Benzodiazepines or Other CNS Depressants
The Suboxone (buprenorphine/naloxone) film label warns about this interaction: "Concomitant use of buprenorphine and benzodiazepines and/or other CNS depressants (e.g., … gabapentinoids [gabapentin or pregabalin] … increases the risk of adverse reactions including overdose" Retrieved from DailyMed 2026-09-27.
Open source
Educational reference only. Not FDA-cleared. The Prescribing Information governs.
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