Buprenorphine and Pregabalin

Desk tier: Serious concern

Mechanism: gabapentinoid × opioid (respiratory depression)

“Concomitant use of buprenorphine and benzodiazepines and/or other CNS depressants (e.g., … gabapentinoids [gabapentin or pregabalin] … increases the risk of adverse reactions including overdose”

Suboxone (buprenorphine/naloxone) film, section 5.3 Managing Risks from Concomitant Use of Benzodiazepines or Other CNS Depressants. DailyMed label

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All pairs for Buprenorphine · Pregabalin

Educational reference only. Not FDA-cleared. The Prescribing Information governs.