Sotalol interactions on FDA labels
These are pairs with Sotalol where an FDA label names an interaction, grouped by the desk's grade. A drug that isn't listed here hasn't been cleared as safe with Sotalol; it just isn't on this list. Open any pair in the desk to see it alongside other drugs.
Avoid together
- Sotalol and Ziprasidone
Why this grade
Geodon (ziprasidone) label, Contraindications
The Geodon (ziprasidone) label lists this combination under Contraindications. 4.1 QT Prolongation: "ziprasidone is contraindicated: … Therefore, ziprasidone should not be given with:" Named in the label: "sotalol" Retrieved from DailyMed 2026-10-03.
Open source
Serious concern
- Sotalol and Methadone
Why this grade
Methadone HCl tablets label, Boxed Warning (Life-Threatening QT Prolongation); 5.4; 7 DRUG INTERACTIONS
The Methadone HCl tablets label names this interaction in its Boxed Warning: "Closely monitor patients with risk factors for development of prolonged QT interval, … and those taking medications affecting cardiac conduction" Retrieved from DailyMed 2026-09-27.
Open source
Educational reference only. Not FDA-cleared. The Prescribing Information governs.
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