All pairs

Methadone and Sotalol

Desk tier: Serious concern

Mechanism: methadone QT stack (additive QT prolongation / TdP)

“Closely monitor patients with risk factors for development of prolonged QT interval, … and those taking medications affecting cardiac conduction”
Methadone HCl tablets, section Boxed Warning (Life-Threatening QT Prolongation); 5.4; 7 DRUG INTERACTIONS. DailyMed label

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All pairs for Methadone · Sotalol

Educational reference only. Not FDA-cleared. The Prescribing Information governs.