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Atazanavir–cobicistat and St. John's wort

Desk tier: Avoid together

Mechanism: strong CYP3A4 induction of clearance (↓ exposure / loss of efficacy)

“The concomitant use of EVOTAZ and the following drugs in Table 1, are contraindicated”
Evotaz (atazanavir/cobicistat), section 4 CONTRAINDICATIONS (Table 1). DailyMed label

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All pairs for Atazanavir–cobicistat · St. John's wort

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.