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Clarithromycin and Ergotamine

Desk tier: Avoid together

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“Concomitant administration of clarithromycin and ergotamine or dihydroergotamine is contraindicated”
Clarithromycin tablets, section 4 CONTRAINDICATIONS. DailyMed label

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All pairs for Clarithromycin · Ergotamine

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.