Ergotamine interactions on FDA labels
These are pairs with Ergotamine where an FDA label names an interaction, grouped by the desk's grade. A drug that isn't listed here hasn't been cleared as safe with Ergotamine; it just isn't on this list. Open any pair in the desk to see it alongside other drugs.
Avoid together
- Ergotamine and Atazanavir
Why this grade
Reyataz (atazanavir) label, Contraindications
The Reyataz (atazanavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS (Table 6): "Coadministration is contraindicated with, but not limited to, the following drugs" Named in the label: "Ergot Derivatives Dihydroergotamine, ergonovine, ergotamine, methylergonovine" Retrieved from DailyMed 2026-10-02.
Open source - Ergotamine and Atazanavir–cobicistat
Why this grade
Evotaz (atazanavir/cobicistat) label, Contraindications
The Evotaz (atazanavir/cobicistat) label lists this combination under Contraindications. 4 CONTRAINDICATIONS (Table 1): "The concomitant use of EVOTAZ and the following drugs in Table 1, are contraindicated" Named in the label: "Ergot Derivatives dihydroergotamine, ergotamine, methylergonovine" Retrieved from DailyMed 2026-10-02.
Open source - Ergotamine and Clarithromycin
Why this grade
Clarithromycin tablets label, Contraindications
The Clarithromycin tablets label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "Concomitant administration of clarithromycin and ergotamine or dihydroergotamine is contraindicated" Retrieved from DailyMed 2026-10-02.
Open source - Ergotamine and Darunavir
Why this grade
Prezista (darunavir) label, Contraindications
The Prezista (darunavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "Examples of these drugs and other contraindicated drugs (which may lead to reduced efficacy of darunavir) are listed below" Named in the label: "Ergot derivatives, e.g. dihydroergotamine, ergotamine, methylergonovine" Retrieved from DailyMed 2026-10-02.
Open source - Ergotamine and Darunavir–cobicistat
Why this grade
Prezcobix (darunavir/cobicistat) label, Contraindications
The Prezcobix (darunavir/cobicistat) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "Examples of drugs that are contraindicated for co-administration with PREZCOBIX" Named in the label: "Ergot derivatives, e.g. dihydroergotamine, ergotamine, methylergonovine" Retrieved from DailyMed 2026-10-02.
Open source - Ergotamine and Erythromycin
Why this grade
Cafergot (ergotamine/caffeine) label, Contraindications
The Cafergot (ergotamine/caffeine) label lists this combination under Contraindications. CONTRAINDICATIONS: "Coadministration of ergotamine with potent CYP 3A4 inhibitors (ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, and troleandomycin) … ergotamine use is contraindicated with these drugs" Named in the label: "erythromycin" Retrieved from DailyMed 2026-10-12.
Open source - Ergotamine and Itraconazole
Why this grade
Sporanox (itraconazole) label, Contraindications
The Sporanox (itraconazole) label lists this combination under Contraindications. CONTRAINDICATIONS: "Coadministration of a number of CYP3A4 substrates are contraindicated with SPORANOX®." Named in the label: "ergotamine" Retrieved from DailyMed 2026-10-02.
Open source - Ergotamine and Ketoconazole
Why this grade
Cafergot (ergotamine/caffeine) label, Contraindications
The Cafergot (ergotamine/caffeine) label lists this combination under Contraindications. CONTRAINDICATIONS: "ergotamine use is contraindicated with these drugs and other potent inhibitors of CYP 3A4 (e.g., ketoconazole, itraconazole)" Named in the label: "ketoconazole" Retrieved from DailyMed 2026-10-12.
Open source - Ergotamine and Lopinavir/ritonavir
Why this grade
Kaletra (lopinavir/ritonavir) label, Contraindications
The Kaletra (lopinavir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "KALETRA is contraindicated with drugs that are highly dependent on CYP3A for clearance" Named in the label: "Ergot Derivatives: dihydroergotamine, ergotamine, methylergonovine" Retrieved from DailyMed 2026-10-02.
Open source - Ergotamine and Mifepristone
Why this grade
Korlym (mifepristone) label, Contraindications
The Korlym (mifepristone) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "KORLYM is contraindicated in: … Patients taking drugs metabolized by CYP3A such as simvastatin, lovastatin" Named in the label: "such as cyclosporine, dihydroergotamine, ergotamine, fentanyl, pimozide, quinidine, sirolimus, and tacrolimus" Retrieved from DailyMed 2026-10-02.
Open source - Ergotamine and Paxlovid (nirmatrelvir/ritonavir)
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Ergot derivatives: dihydroergotamine, ergotamine, methylergonovine" Retrieved from DailyMed 2026-10-02.
Open source - Ergotamine and Posaconazole
Why this grade
Noxafil (posaconazole) label, Contraindications
The Noxafil (posaconazole) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "Coadministration of Noxafil with the following drugs is contraindicated" Named in the label: "ergot alkaloids (ergotamine and dihydroergotamine)" Retrieved from DailyMed 2026-10-02.
Open source - Ergotamine and Ritonavir
Why this grade
Cafergot (ergotamine/caffeine) label, Contraindications
The Cafergot (ergotamine/caffeine) label lists this combination under Contraindications. CONTRAINDICATIONS: "Coadministration of ergotamine with potent CYP 3A4 inhibitors (ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, and troleandomycin) has been associated with acute ergot toxicity" Retrieved from DailyMed 2026-09-27.
Open source
Enzyme roles on the desk
- CYP3A4 · major-pathway substrate
Educational reference only. Not FDA-cleared. The Prescribing Information governs.
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