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Clopidogrel and Esomeprazole

Desk tier: Serious concern

Mechanism: moderate CYP2C19 inhibition of prodrug activation (↓ active metabolite)

“Avoid concomitant use of Plavix with omeprazole or esomeprazole.”
Plavix (clopidogrel), section 7.2 CYP2C19 Inhibitors. DailyMed label

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All pairs for Clopidogrel · Esomeprazole

Enzyme behind this pair: CYP2C19

Educational reference only. Not FDA-cleared. The Prescribing Information governs.