Clopidogrel interactions on FDA labels

These are pairs with Clopidogrel where an FDA label names an interaction, grouped by the desk's grade. A drug that isn't listed here hasn't been cleared as safe with Clopidogrel; it just isn't on this list. Open any pair in the desk to see it alongside other drugs.

Open Clopidogrel in the desk

Serious concern

Clopidogrel and Esomeprazole
Why this grade
Plavix (clopidogrel) label, 7.2 CYP2C19 Inhibitors
The Plavix (clopidogrel) label says to avoid this combination: "Avoid concomitant use of Plavix with omeprazole or esomeprazole." Retrieved from DailyMed 2026-09-27.
Open source
Clopidogrel and Omeprazole
Why this grade
Prescribing Information
Plavix boxed warning / FDA PPI communication: omeprazole and esomeprazole phenocopy CYP2C19 PM and blunt clopidogrel activation. Pantoprazole is the quieter PPI on this desk.
Open source

Enzyme roles on the desk

CYP2B6 · weak inhibitor
CYP2C8 · moderate inhibitor
CYP2C19 · sensitive substrate (activation pathway)
CYP3A4 · minor-pathway substrate (activation pathway)

Educational reference only. Not FDA-cleared. The Prescribing Information governs.

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