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Clopidogrel and Omeprazole

Desk tier: Serious concern

Mechanism: omeprazole / esomeprazole 2C19 phenocopy (loss of clopidogrel activation)

“Avoid concomitant use of Plavix with omeprazole or esomeprazole.”
Plavix (clopidogrel), section 7.2 CYP2C19 Inhibitors. DailyMed label

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All pairs for Clopidogrel · Omeprazole

Educational reference only. Not FDA-cleared. The Prescribing Information governs.