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Darunavir and St. John's wort

Desk tier: Avoid together

Mechanism: strong CYP3A4 induction of clearance (↓ exposure / loss of efficacy)

“Examples of these drugs and other contraindicated drugs (which may lead to reduced efficacy of darunavir) are listed below”
Prezista (darunavir), section 4 CONTRAINDICATIONS. DailyMed label

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All pairs for Darunavir · St. John's wort

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.