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Dihydroergotamine and Erythromycin

Desk tier: Avoid together

Mechanism: moderate CYP3A4 inhibition of clearance (↑ exposure)

“The use of potent CYP3A4 inhibitors (i.e., ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, troleandomycin, ketoconazole, itraconazole) with dihydroergotamine is, therefore contraindicated”
Dihydroergotamine mesylate injection, section CONTRAINDICATIONS. DailyMed label

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All pairs for Dihydroergotamine · Erythromycin

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.