Dronedarone and Nefazodone

Desk tier: Avoid together

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“Concomitant use of strong CYP3A inhibitors, such as ketoconazole, itraconazole, voriconazole, cyclosporine, telithromycin, clarithromycin, nefazodone, and ritonavir”

Multaq (dronedarone), section 4 CONTRAINDICATIONS. DailyMed label

Open this pair in the desk

All pairs for Dronedarone · Nefazodone

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.