Nefazodone interactions on FDA labels
These are pairs with Nefazodone where an FDA label names an interaction, grouped by the desk's grade. A drug that isn't listed here hasn't been cleared as safe with Nefazodone; it just isn't on this list. Open any pair in the desk to see it alongside other drugs.
Avoid together
- Nefazodone and Carbamazepine
Why this grade
Tegretol (carbamazepine) label, Contraindications
The Tegretol (carbamazepine) label lists this combination under Contraindications. CONTRAINDICATIONS: "Coadministration of carbamazepine with nefazodone is contraindicated." Named in the label: "nefazodone" Retrieved from DailyMed 2026-10-12.
Open source - Nefazodone and Dronedarone
Why this grade
Multaq (dronedarone) label, Contraindications
The Multaq (dronedarone) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "Concomitant use of strong CYP3A inhibitors, such as ketoconazole, itraconazole, voriconazole, cyclosporine, telithromycin, clarithromycin, nefazodone, and ritonavir" Named in the label: "nefazodone" Retrieved from DailyMed 2026-10-12.
Open source - Nefazodone and Eletriptan
Why this grade
Relpax (eletriptan) label, Contraindications
The Relpax (eletriptan) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "Recent use (i.e., within at least 72 hours) of the following potent CYP3A4 inhibitors: ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, or nelfinavir" Named in the label: "nefazodone" Retrieved from DailyMed 2026-10-12.
Open source - Nefazodone and Eplerenone
Why this grade
Inspra (eplerenone) label, Contraindications
The Inspra (eplerenone) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "INSPRA is contraindicated in all patients with: … concomitant administration of strong CYP3A inhibitors (e.g., ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, and nelfinavir)" Named in the label: "nefazodone" Retrieved from DailyMed 2026-10-12.
Open source - Nefazodone and Pimozide
Why this grade
Pimozide label, Contraindications
The Pimozide label lists this combination under Contraindications. CONTRAINDICATIONS: "Nefazodone is a potent inhibitor of CYP 3A4, and its concomitant use with pimozide is also contraindicated" Named in the label: "Nefazodone" Retrieved from DailyMed 2026-10-12.
Open source - Nefazodone and Tranylcypromine
Why this grade
Parnate (tranylcypromine) label, Contraindications
The Parnate (tranylcypromine) label lists this combination under Contraindications. 4.1 Combination with Certain Drugs: "Concomitant use of PARNATE or use in rapid succession with the products in Table 1 is contraindicated … Other antidepressants (e.g., … nefazodone" Named in the label: "nefazodone" Retrieved from DailyMed 2026-10-12.
Open source - Nefazodone and Triazolam
Why this grade
Triazolam label, Contraindications
The Triazolam label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "Triazolam is contraindicated in: … Concomitant administration of strong cytochrome P450 (CYP 3A) enzyme inhibitors (e.g., ketoconazole, itraconazole, nefazodone, lopinavir, ritonavir)" Named in the label: "nefazodone" Retrieved from DailyMed 2026-10-12.
Open source
Enzyme roles on the desk
- CYP3A4 · major-pathway substrate · strong inhibitor
Educational reference only. Not FDA-cleared. The Prescribing Information governs.
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