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Ergotamine and Ketoconazole

Desk tier: Avoid together

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“ergotamine use is contraindicated with these drugs and other potent inhibitors of CYP 3A4 (e.g., ketoconazole, itraconazole)”
Cafergot (ergotamine/caffeine), section CONTRAINDICATIONS. DailyMed label

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All pairs for Ergotamine · Ketoconazole

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.