Ergotamine and troleandomycin
Desk tier: Avoid together
Mechanism: labeled contraindication (labeled contraindication)
“Coadministration of ergotamine with potent CYP 3A4 inhibitors (ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, and troleandomycin) … ergotamine use is contraindicated with these drugs”
Why this grade
Cafergot (ergotamine/caffeine) label, Contraindications
The Cafergot (ergotamine/caffeine) label lists this combination under Contraindications. CONTRAINDICATIONS: "Coadministration of ergotamine with potent CYP 3A4 inhibitors (ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, and troleandomycin) … ergotamine use is contraindicated with these drugs" Named in the label: "troleandomycin" Retrieved from DailyMed 2026-10-12.
Cafergot (ergotamine/caffeine) label on DailyMedAll pairs for Ergotamine · troleandomycin
Educational reference only. Not FDA-cleared. The Prescribing Information governs.
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