Erythromycin and terfenadine
Desk tier: Avoid together
Mechanism: labeled contraindication (labeled contraindication)
“Erythromycin is contraindicated in patients taking terfenadine, astemizole, cisapride, pimozide, ergotamine, or dihydroergotamine.”
Why this grade
Erythromycin label, Contraindications
The Erythromycin label lists this combination under Contraindications. Contraindications: "Erythromycin is contraindicated in patients taking terfenadine, astemizole, cisapride, pimozide, ergotamine, or dihydroergotamine." Named in the label: "terfenadine" Retrieved from DailyMed 2026-10-03.
Erythromycin label on DailyMedPMID 18043468
2007 Ther Drug Monit. Zhou. Macrolides, ritonavir, diltiazem/verapamil destroy 3A4. New enzyme, not dissociation. The TDI linger on this desk.
PMID 18043468 on PubMedAll pairs for Erythromycin · terfenadine
Educational reference only. Not FDA-cleared. The Prescribing Information governs.
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