Isocarboxazid and Cocaine
Desk tier: Avoid together
Mechanism: MAOI × stimulant (hypertensive crisis)
“Patients taking Marplan should not undergo elective surgery requiring general anesthesia. Also, they should not be given cocaine”
Why this grade
Marplan (isocarboxazid) label, Contraindications
The Marplan (isocarboxazid) label lists this combination under Contraindications. CONTRAINDICATIONS: "Patients taking Marplan should not undergo elective surgery requiring general anesthesia. Also, they should not be given cocaine" Named in the label: "cocaine" Retrieved from DailyMed 2026-10-19.
Marplan (isocarboxazid) label on DailyMedFDA boxed / safety communication
Amphetamine and methylphenidate labels contraindicate use during or within 14 days after an MAOI (hypertensive crisis). Cocaine, MDMA, and other unlabeled stimulants are the desk extending that label; open the PI.
Search DailyMed for AmphetaminePMID 7870932
1993 Psychopharmacology. McCance-Katz. Cocaine plus ethanol is a third drug.
PMID 7870932 on PubMedAll pairs for Isocarboxazid · Cocaine
Educational reference only. Not FDA-cleared. The Prescribing Information governs.
Drug and product names are trademarks of their owners and are used only to identify the products.