All pairs

Lopinavir/ritonavir and St. John's wort

Desk tier: Avoid together

Mechanism: strong CYP3A4 induction of clearance (↓ exposure / loss of efficacy)

“KALETRA is contraindicated with drugs that are potent CYP3A inducers”
Kaletra (lopinavir/ritonavir), section 4 CONTRAINDICATIONS. DailyMed label

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All pairs for Lopinavir/ritonavir · St. John's wort

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.