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Lovastatin and Clarithromycin

Desk tier: Avoid together

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“Concomitant administration with strong CYP3A4 inhibitors (e.g., itraconazole, ketoconazole, … erythromycin, clarithromycin, telithromycin”
Lovastatin tablets, section CONTRAINDICATIONS. DailyMed label

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All pairs for Lovastatin · Clarithromycin

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.