Lovastatin interactions on FDA labels
These are pairs with Lovastatin where an FDA label names an interaction, grouped by the desk's grade. A drug that isn't listed here hasn't been cleared as safe with Lovastatin; it just isn't on this list. Open any pair in the desk to see it alongside other drugs.
Avoid together
- Lovastatin and Atazanavir
Why this grade
Reyataz (atazanavir) label, Contraindications
The Reyataz (atazanavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS (Table 6): "Coadministration is contraindicated with, but not limited to, the following drugs" Named in the label: "Lipid-Modifying Agents: Lomitapide, lovastatin, simvastatin" Retrieved from DailyMed 2026-10-02.
Open source - Lovastatin and Atazanavir–cobicistat
Why this grade
Evotaz (atazanavir/cobicistat) label, Contraindications
The Evotaz (atazanavir/cobicistat) label lists this combination under Contraindications. 4 CONTRAINDICATIONS (Table 1): "The concomitant use of EVOTAZ and the following drugs in Table 1, are contraindicated" Named in the label: "Lipid-modifying Agents lomitapide, lovastatin, simvastatin" Retrieved from DailyMed 2026-10-02.
Open source - Lovastatin and Clarithromycin
Why this grade
Lovastatin tablets label, Contraindications
The Lovastatin tablets label lists this combination under Contraindications. CONTRAINDICATIONS: "Concomitant administration with strong CYP3A4 inhibitors (e.g., itraconazole, ketoconazole, … erythromycin, clarithromycin, telithromycin" Retrieved from DailyMed 2026-09-27.
Open source - Lovastatin and Darunavir
Why this grade
Prezista (darunavir) label, Contraindications
The Prezista (darunavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "Examples of these drugs and other contraindicated drugs (which may lead to reduced efficacy of darunavir) are listed below" Named in the label: "Lipid modifying agents: lomitapide, lovastatin, simvastatin" Retrieved from DailyMed 2026-10-02.
Open source - Lovastatin and Darunavir–cobicistat
Why this grade
Prezcobix (darunavir/cobicistat) label, Contraindications
The Prezcobix (darunavir/cobicistat) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "Examples of drugs that are contraindicated for co-administration with PREZCOBIX" Named in the label: "Lipid modifying agents: lomitapide, lovastatin, simvastatin" Retrieved from DailyMed 2026-10-02.
Open source - Lovastatin and Itraconazole
Why this grade
Sporanox (itraconazole) label, Contraindications
The Sporanox (itraconazole) label lists this combination under Contraindications. CONTRAINDICATIONS: "Coadministration of a number of CYP3A4 substrates are contraindicated with SPORANOX®." Named in the label: "lovastatin" Retrieved from DailyMed 2026-10-02.
Open source - Lovastatin and Lonafarnib
Why this grade
Zokinvy (lonafarnib) label, Contraindications
The Zokinvy (lonafarnib) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "ZOKINVY is contraindicated in patients taking: … Lovastatin, simvastatin, or atorvastatin" Named in the label: "Lovastatin" Retrieved from DailyMed 2026-10-12.
Open source - Lovastatin and Lopinavir/ritonavir
Why this grade
Kaletra (lopinavir/ritonavir) label, Contraindications
The Kaletra (lopinavir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "KALETRA is contraindicated with drugs that are highly dependent on CYP3A for clearance" Named in the label: "HMG-CoA Reductase Inhibitors: lovastatin, simvastatin" Retrieved from DailyMed 2026-10-02.
Open source - Lovastatin and Mifepristone
Why this grade
Korlym (mifepristone) label, Contraindications
The Korlym (mifepristone) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "KORLYM is contraindicated in: … Patients taking drugs metabolized by CYP3A such as simvastatin, lovastatin" Retrieved from DailyMed 2026-10-02.
Open source - Lovastatin and Paxlovid (nirmatrelvir/ritonavir)
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "HMG-CoA reductase inhibitors: lovastatin, simvastatin" Retrieved from DailyMed 2026-10-02.
Open source - Lovastatin and Posaconazole
Why this grade
Noxafil (posaconazole) label, Contraindications
The Noxafil (posaconazole) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "Coadministration with the HMG-CoA reductase inhibitors that are primarily metabolized through CYP3A4 (e.g., atorvastatin, lovastatin, and simvastatin) is contraindicated" Retrieved from DailyMed 2026-10-02.
Open source - Lovastatin and Ritonavir
Why this grade
Norvir (ritonavir) label, Contraindications
The Norvir (ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "NORVIR is contraindicated with drugs that are highly dependent on CYP3A for clearance" Named in the label: "HMG-CoA Reductase Inhibitors: lovastatin, simvastatin" Retrieved from DailyMed 2026-10-02.
Open source
Enzyme roles on the desk
- CYP3A4 · sensitive substrate
Educational reference only. Not FDA-cleared. The Prescribing Information governs.
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