Naltrexone and Buprenorphine

Desk tier: Avoid together

Mechanism: opioid antagonist × agonist (precipitated withdrawal / blocked analgesia)

“Naltrexone hydrochloride is contraindicated in: … Patients currently dependent on opioids, including those currently maintained on … partial agonists (e.g., buprenorphine).”

Naltrexone HCl tablets, section CONTRAINDICATIONS. DailyMed label

Open this pair in the desk

All pairs for Naltrexone · Buprenorphine

Educational reference only. Not FDA-cleared. The Prescribing Information governs.