Naltrexone interactions on FDA labels
These are pairs with Naltrexone where an FDA label names an interaction, grouped by the desk's grade. A drug that isn't listed here hasn't been cleared as safe with Naltrexone; it just isn't on this list. Open any pair in the desk to see it alongside other drugs.
Avoid together
- Naltrexone and Buprenorphine
Why this grade
Naltrexone HCl tablets label, Contraindications
The Naltrexone HCl tablets label lists this combination under Contraindications. CONTRAINDICATIONS: "Naltrexone hydrochloride is contraindicated in: … Patients currently dependent on opioids, including those currently maintained on … partial agonists (e.g., buprenorphine)." Retrieved from DailyMed 2026-09-27.
Open source - Naltrexone and Hydrocodone
Why this grade
Vivitrol (naltrexone ER injectable suspension) label, Contraindications
The Vivitrol (naltrexone ER injectable suspension) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "VIVITROL is contraindicated in: … Patients receiving opioid analgesics" Retrieved from DailyMed 2026-09-27.
Open source - Naltrexone and Methadone
Why this grade
Naltrexone HCl tablets label, Contraindications
The Naltrexone HCl tablets label lists this combination under Contraindications. CONTRAINDICATIONS: "Naltrexone hydrochloride is contraindicated in: … Patients currently dependent on opioids, including those currently maintained on opiate agonists (e.g., methadone)" Retrieved from DailyMed 2026-09-27.
Open source - Naltrexone and Oxycodone
Why this grade
Naltrexone HCl tablets label, Contraindications
The Naltrexone HCl tablets label lists this combination under Contraindications. CONTRAINDICATIONS: "Naltrexone hydrochloride is contraindicated in: … Patients receiving opioid analgesics." Retrieved from DailyMed 2026-09-27.
Open source
Educational reference only. Not FDA-cleared. The Prescribing Information governs.
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