Naltrexone and Methadone

Desk tier: Avoid together

Mechanism: opioid antagonist × agonist (precipitated withdrawal / blocked analgesia)

“Naltrexone hydrochloride is contraindicated in: … Patients currently dependent on opioids, including those currently maintained on opiate agonists (e.g., methadone)”

Naltrexone HCl tablets, section CONTRAINDICATIONS. DailyMed label

Open this pair in the desk

All pairs for Naltrexone · Methadone

Educational reference only. Not FDA-cleared. The Prescribing Information governs.