Paxlovid (nirmatrelvir/ritonavir) and Finerenone

Desk tier: Avoid together

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A”

Paxlovid (nirmatrelvir/ritonavir), section 4 CONTRAINDICATIONS. DailyMed label

Why this grade

Paxlovid (nirmatrelvir/ritonavir) label, Contraindications

The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Mineralocorticoid receptor antagonists: finerenone" Retrieved from DailyMed 2026-10-02.

Open source

PMID 10485779

1999 Anesthesiology. Olkkola. Ritonavir cuts fentanyl clearance 67%. Paxlovid is the five-day version of this booster.

Open source

Open this pair in the desk

All pairs for Paxlovid (nirmatrelvir/ritonavir) · Finerenone

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.

Drug and product names are trademarks of their owners and are used only to identify the products.