Paxlovid (nirmatrelvir/ritonavir) interactions on FDA labels
These are pairs with Paxlovid (nirmatrelvir/ritonavir) where an FDA label names an interaction, grouped by the desk's grade. A drug that isn't listed here hasn't been cleared as safe with Paxlovid (nirmatrelvir/ritonavir); it just isn't on this list. Open any pair in the desk to see it alongside other drugs.
Open Paxlovid (nirmatrelvir/ritonavir) in the desk
Avoid together
- Paxlovid (nirmatrelvir/ritonavir) and Alfuzosin
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Alpha 1-adrenoreceptor antagonist: alfuzosin" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Amiodarone
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Antiarrhythmic: amiodarone, dronedarone, flecainide, propafenone, quinidine" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Apalutamide
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A … and drugs that are strong CYP3A inducers" Named in the label: "Anticancer drugs: apalutamide, enzalutamide" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Carbamazepine
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A … and drugs that are strong CYP3A inducers" Named in the label: "Anticonvulsant: carbamazepine, phenobarbital, primidone, phenytoin" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Dihydroergotamine
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Ergot derivatives: dihydroergotamine, ergotamine, methylergonovine" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Dronedarone
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Antiarrhythmic: amiodarone, dronedarone, flecainide, propafenone, quinidine" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Eletriptan
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Migraine medications: eletriptan, ubrogepant" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Enzalutamide
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A … and drugs that are strong CYP3A inducers" Named in the label: "Anticancer drugs: apalutamide, enzalutamide" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Eplerenone
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Cardiovascular agents: eplerenone, ivabradine" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Ergotamine
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Ergot derivatives: dihydroergotamine, ergotamine, methylergonovine" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Finerenone
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Mineralocorticoid receptor antagonists: finerenone" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Flecainide
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Antiarrhythmic: amiodarone, dronedarone, flecainide, propafenone, quinidine" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Ivabradine
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Cardiovascular agents: eplerenone, ivabradine" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Lovastatin
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "HMG-CoA reductase inhibitors: lovastatin, simvastatin" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Lumacaftor–ivacaftor
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A … and drugs that are strong CYP3A inducers" Named in the label: "Cystic fibrosis transmembrane conductance regulator potentiators: lumacaftor/ivacaftor" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Lurasidone
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Antipsychotics: lurasidone, pimozide" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Methylergonovine
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Ergot derivatives: dihydroergotamine, ergotamine, methylergonovine" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Midazolam
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Sedative/hypnotics: triazolam, oral midazolam" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Naloxegol
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Opioid antagonists: naloxegol" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Phenobarbital
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A … and drugs that are strong CYP3A inducers" Named in the label: "Anticonvulsant: carbamazepine, phenobarbital, primidone, phenytoin" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Phenytoin
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A … and drugs that are strong CYP3A inducers" Named in the label: "Anticonvulsant: carbamazepine, phenobarbital, primidone, phenytoin" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Pimozide
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Antipsychotics: lurasidone, pimozide" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Primidone
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A … and drugs that are strong CYP3A inducers" Named in the label: "Anticonvulsant: carbamazepine, phenobarbital, primidone, phenytoin" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Propafenone
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Antiarrhythmic: amiodarone, dronedarone, flecainide, propafenone, quinidine" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Quinidine
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Antiarrhythmic: amiodarone, dronedarone, flecainide, propafenone, quinidine" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Ranolazine
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Antianginal: ranolazine" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Rifampin
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A … and drugs that are strong CYP3A inducers" Named in the label: "Antimycobacterials: rifampin, rifapentine" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Rifapentine
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A … and drugs that are strong CYP3A inducers" Named in the label: "Antimycobacterials: rifampin, rifapentine" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Sildenafil (PAH)
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "PDE5 inhibitor: sildenafil (Revatio®) when used for pulmonary arterial hypertension (PAH)" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Silodosin
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Benign prostatic hyperplasia agents: silodosin" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Simvastatin
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "HMG-CoA reductase inhibitors: lovastatin, simvastatin" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and St. John's wort
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A … and drugs that are strong CYP3A inducers" Named in the label: "Herbal products: St. John's Wort (hypericum perforatum)" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Suzetrigine
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Non-opioid analgesic (selective blocker of Nav1.8 sodium channels): suzetrigine" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Tolvaptan
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Vasopressin receptor antagonists: tolvaptan" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Triazolam
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Sedative/hypnotics: triazolam, oral midazolam" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Ubrogepant
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Migraine medications: eletriptan, ubrogepant" Retrieved from DailyMed 2026-10-02.
Open source - Paxlovid (nirmatrelvir/ritonavir) and Voclosporin
Why this grade
Paxlovid (nirmatrelvir/ritonavir) label, Contraindications
The Paxlovid (nirmatrelvir/ritonavir) label lists this combination under Contraindications. 4 CONTRAINDICATIONS: "PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A" Named in the label: "Immunosuppressants: voclosporin" Retrieved from DailyMed 2026-10-02.
Open source
Enzyme roles on the desk
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