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Paxlovid (nirmatrelvir/ritonavir) and Propafenone

Desk tier: Avoid together

Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)

“PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A”
Paxlovid (nirmatrelvir/ritonavir), section 4 CONTRAINDICATIONS. DailyMed label

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All pairs for Paxlovid (nirmatrelvir/ritonavir) · Propafenone

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.