Pimozide and Erythromycin

Desk tier: Avoid together

Mechanism: moderate CYP3A4 inhibition of clearance (↑ exposure)

“pimozide is contraindicated in patients receiving the macrolide antibiotics clarithromycin, erythromycin, azithromycin, dirithromycin, and troleandomycin”

Pimozide, section CONTRAINDICATIONS. DailyMed label

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All pairs for Pimozide · Erythromycin

Enzyme behind this pair: CYP3A4

Educational reference only. Not FDA-cleared. The Prescribing Information governs.