Pimozide and Nefazodone
Desk tier: Avoid together
Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)
“Nefazodone is a potent inhibitor of CYP 3A4, and its concomitant use with pimozide is also contraindicated”
Why this grade
Pimozide label, Contraindications
The Pimozide label lists this combination under Contraindications. CONTRAINDICATIONS: "Nefazodone is a potent inhibitor of CYP 3A4, and its concomitant use with pimozide is also contraindicated" Named in the label: "Nefazodone" Retrieved from DailyMed 2026-10-12.
Open sourceFDA interaction table
FDA's example-interaction table lists Nefazodone as a strong CYP3A inhibitor, and Pimozide as a moderately sensitive CYP3A substrate. FDA grades the roles; the severity tier on this row is the desk's rule. Table content current as of 2026-05-29.
Open sourceNefazodone label, Contraindications
The Nefazodone label calls this combination contraindicated: "Coadministration of terfenadine, astemizole, cisapride, pimozide, or carbamazepine with nefazodone hydrochloride is contraindicated" Retrieved from DailyMed 2026-10-02.
Open sourceAll pairs for Pimozide · Nefazodone
Enzyme behind this pair: CYP3A4
Educational reference only. Not FDA-cleared. The Prescribing Information governs.
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