Posaconazole and Lovastatin
Desk tier: Avoid together
Mechanism: strong CYP3A4 inhibition of clearance (↑ exposure)
“Coadministration with the HMG-CoA reductase inhibitors that are primarily metabolized through CYP3A4 (e.g., atorvastatin, lovastatin, and simvastatin) is contraindicated”
All pairs for Posaconazole · Lovastatin
Enzyme behind this pair: CYP3A4
Educational reference only. Not FDA-cleared. The Prescribing Information governs.